Barcelona is the most in-form team in Europe after racking up 17 wins in its last 18 official matches.
The Argentine striker for Atlético Madrid has not scored in two months. His last goal was on 9 December against PSV in the sixth match of the Champions League group stage.
Barcelona, Real Sociedad, Athletic and Atlético Madrid will contest the Copa del Rey semi-finals after coming through their quarter-final ties.
The draw held on Monday 19 January at the headquarters of the Spanish Football Federation determined the pairings for the quarter-finals of the Cup. Albacete, the only representative from the Second Division, will face Barcelona.